Pediatric Surgery Research Laboratory
Clinical Sciences Building, L017, L022, L020
2500 North State Street
Jackson, MS 39216
Director Ujjwal K Rout, MPhil, PhD ( email )
The Pediatric Surgery Research Laboratory conducts interdisciplinary research work using cell lines and animal models. Projects seek to understand disease mechanisms in the developmental context. Because development of organisms requires an intricate balance of proliferation, migration, differentiation and death of different cell types at specific times and in specific locations, our research focuses on the regulatory mechanisms of basic cellular events. This includes studies on transcription factors, adhesion molecules and transcripts of various gene products using biochemical, cellular and molecular tools. Techniques include semi-quantitative RT-PCR, RNAi, Gene arrays, immunofluorescent microscopy, cell migration assays, live cell imaging and Western blotting.
We maintain different cell lines to address biological problems involving brain, heart, muscle, prostrate, placenta and stem cells from mice to suit the interests of researchers. Additional cell lines and animal models techniques will be included with the requirements of projects. Current projects include study of the effects of maternal alcohol consumption on the migration of neurons during development in a rat model and effects of different drugs (Valproate, Thalidomide and alcohol) on the proliferation and differentiation of neuron-like PC12 cells. Several other projects are under development.
|
